Clinico-pathological study of thymic dysplasia.
نویسندگان
چکیده
In a recent necropsy study of a thousand cases in which adequate amounts of thymus gland were available, Berry (1968) found a large number of abnormalities. Most of these were related to the lymphocyte population and in some cases apparently resulted from the exhibition of cytotoxic drugs or steroid hormones. In 17 cases epithelial abnormalities were found, these glands showing lymphocyte depletion associated with absence of, or reduction in, the number of Hassal's corpuscles to less than 5% of the normal numbers for the age. The normal data were derived from Boyd (1932). In all 14 ofthese 17 cases in which adequate material remained for examination, other abnormalities of lymphoid organs were found. The clinical histories of these 17 have been reviewed, and in 14 where adequate data were available, a clinico-pathological correlation was attempted. The clinical and pathological findings are summarized in Tables I and II: photomicrographs of classical thymic, lymph node, and appendiceal abnormalities are shown in Fig. 1, 2, and 3.
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عنوان ژورنال:
- Archives of disease in childhood
دوره 43 231 شماره
صفحات -
تاریخ انتشار 1968